Rare and low-frequency coding variants alter human adult height

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F., Frayling, Timothy M. , Hirschhorn, Joel N. , Deloukas, Panos, Lettre, Guillaume and make_name_string expected hash reference (2017) Rare and low-frequency coding variants alter human adult height. Nature 542 (7640), pp. 186-190.

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Other URL: http://doi.org/10.1038/nature21039

Abstract

Height is a highly heritable, classic polygenic trait with approximately 700 common associated variants identified through genome-wide association studies so far. Here, we report 83 height-associated coding variants with lower minor-allele frequencies (in the range of 0.1-4.8%) and effects of up to 2 centimetres per allele (such as those in IHH, STC2, AR and CRISPLD2), greater than ten times the ...