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PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study

Schmidt, Amand F. ; Swerdlow, Daniel I. ; Holmes, Michael V. ; Patel, Riyaz S. ; Fairhurst-Hunter, Zammy ; Lyall, Donald M. ; Hartwig, Fernando Pires ; Horta, Bernardo Lessa ; Hyppönen, Elina ; Power, Christine ; Moldovan, Max ; van Iperen, Erik ; Hovingh, G. Kees ; Demuth, Ilja ; Norman, Kristina ; Steinhagen-Thiessen, Elisabeth ; Demuth, Juri ; Bertram, Lars ; Liu, Tian ; Coassin, Stefan ; Willeit, Johann ; Kiechl, Stefan ; Willeit, Karin ; Mason, Dan ; Wright, John ; Morris, Richard ; Wanamethee, Goya ; Whincup, Peter ; Ben-Shlomo, Yoav ; McLachlan, Stela ; Price, Jackie F. ; Kivimaki, Mika ; Welch, Catherine ; Sanchez-Galvez, Adelaida ; Marques-Vidal, Pedro ; Nicolaides, Andrew ; Panayiotou, Andrie G. ; Onland-Moret, N. Charlotte ; van der Schouw, Yvonne T. ; Matullo, Giuseppe ; Fiorito, Giovanni ; Guarrera, Simonetta ; Sacerdote, Carlotta ; Wareham, Nicholas J. ; Langenberg, Claudia ; Scott, Robert ; Luan, Jian'an ; Bobak, Martin ; Malyutina, Sofia ; Pająk, Andrzej ; Kubinova, Ruzena ; Tamosiunas, Abdonas ; Pikhart, Hynek ; Husemoen, Lise Lotte Nystrup ; Grarup, Niels ; Pedersen, Oluf ; Hansen, Torben ; Linneberg, Allan ; Simonsen, Kenneth Starup ; Cooper, Jackie ; Humphries, Steve E. ; Brilliant, Murray ; Kitchner, Terrie ; Hakonarson, Hakon ; Carrell, David S. ; McCarty, Catherine A. ; Kirchner, H. Lester ; Larson, Eric B. ; Crosslin, David R. ; de Andrade, Mariza ; Roden, Dan M. ; Denny, Joshua C. ; Carty, Cara ; Hancock, Stephen ; Attia, John ; Holliday, Elizabeth ; O'Donnell, Martin ; Yusuf, Salim ; Chong, Michael ; Pare, Guillaume ; van der Harst, Pim ; Said, M. Abdullah ; Eppinga, Ruben N. ; Verweij, Niek ; Snieder, Harold ; Christen, Tim ; Mook-Kanamori, Dennis O. ; Gustafsson, Stefan ; Lind, Lars ; Ingelsson, Erik ; Pazoki, Raha ; Franco, Oscar ; Hofman, Albert ; Uitterlinden, Andre ; Dehghan, Abbas ; Teumer, Alexander ; Baumeister, Sebastian ; Dörr, Marcus ; Lerch, Markus M. ; Völker, Uwe ; Völzke, Henry ; Ward, Joey ; Pell, Jill P. ; Smith, Daniel J. ; Meade, Tom ; Maitland-van der Zee, Anke H. ; Baranova, Ekaterina V. ; Young, Robin ; Ford, Ian ; Campbell, Archie ; Padmanabhan, Sandosh ; Bots, Michiel L. ; Grobbee, Diederick E. ; Froguel, Philippe ; Thuillier, Dorothée ; Balkau, Beverley ; Bonnefond, Amélie ; Cariou, Bertrand ; Smart, Melissa ; Bao, Yanchun ; Kumari, Meena ; Mahajan, Anubha ; Ridker, Paul M. ; Chasman, Daniel I. ; Reiner, Alex P. ; Lange, Leslie A. ; Ritchie, Marylyn D. ; Asselbergs, Folkert W. ; Casas, Juan-Pablo ; Keating, Brendan J. ; Preiss, David ; Hingorani, Aroon D. ; Sattar, Naveed



Abstract

Background Statin treatment and variants in the gene encoding HMG-CoA reductase are associated with reductions in both the concentration of LDL cholesterol and the risk of coronary heart disease, but also with modest hyperglycaemia, increased bodyweight, and modestly increased risk of type 2 diabetes, which in no way off sets their substantial benefi ts. We sought to investigate the associations ...

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