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PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study

Schmidt, Amand F , Swerdlow, Daniel I , Holmes, Michael V, Patel, Riyaz S, Fairhurst-Hunter, Zammy, Lyall, Donald M, Hartwig, Fernando Pires, Horta, Bernardo Lessa , Hyppönen, Elina , Power, Christine, Moldovan, Max, van Iperen, Erik, Hovingh, G Kees, Demuth, Ilja , Norman, Kristina , Steinhagen-Thiessen, Elisabeth, Demuth, Juri , Bertram, Lars , Liu, Tian, Coassin, Stefan , Willeit, Johann, Kiechl, Stefan, Willeit, Karin, Mason, Dan , Wright, John , Morris, Richard , Wanamethee, Goya, Whincup, Peter, Ben-Shlomo, Yoav, McLachlan, Stela, Price, Jackie F, Kivimaki, Mika, Welch, Catherine , Sanchez-Galvez, Adelaida, Marques-Vidal, Pedro, Nicolaides, Andrew, Panayiotou, Andrie G, Onland-Moret, N Charlotte , van der Schouw, Yvonne T , Matullo, Giuseppe, Fiorito, Giovanni, Guarrera, Simonetta, Sacerdote, Carlotta, Wareham, Nicholas J, Langenberg, Claudia, Scott, Robert, Luan, Jian'an, Bobak, Martin, Malyutina, Sofia , Pająk, Andrzej, Kubinova, Ruzena, Tamosiunas, Abdonas, Pikhart, Hynek , Husemoen, Lise Lotte Nystrup, Grarup, Niels , Pedersen, Oluf , Hansen, Torben , Linneberg, Allan , Simonsen, Kenneth Starup, Cooper, Jackie, Humphries, Steve E, Brilliant, Murray, Kitchner, Terrie, Hakonarson, Hakon, Carrell, David S, McCarty, Catherine A , Kirchner, H Lester, Larson, Eric B, Crosslin, David R, de Andrade, Mariza, Roden, Dan M, Denny, Joshua C , Carty, Cara, Hancock, Stephen, Attia, John, Holliday, Elizabeth, O'Donnell, Martin, Yusuf, Salim, Chong, Michael , Pare, Guillaume , van der Harst, Pim, Said, M Abdullah , Eppinga, Ruben N, Verweij, Niek , Snieder, Harold, Christen, Tim , Mook-Kanamori, Dennis O, Gustafsson, Stefan, Lind, Lars, Ingelsson, Erik, Pazoki, Raha, Franco, Oscar, Hofman, Albert, Uitterlinden, Andre, Dehghan, Abbas , Teumer, Alexander, Baumeister, Sebastian, Dörr, Marcus, Lerch, Markus M , Völker, Uwe, Völzke, Henry, Ward, Joey, Pell, Jill P , Smith, Daniel J , Meade, Tom, Maitland-van der Zee, Anke H, Baranova, Ekaterina V, Young, Robin, Ford, Ian, Campbell, Archie, Padmanabhan, Sandosh, Bots, Michiel L, Grobbee, Diederick E, Froguel, Philippe, Thuillier, Dorothée, Balkau, Beverley, Bonnefond, Amélie , Cariou, Bertrand, Smart, Melissa , Bao, Yanchun, Kumari, Meena, Mahajan, Anubha , Ridker, Paul M, Chasman, Daniel I, Reiner, Alex P, Lange, Leslie A, Ritchie, Marylyn D, Asselbergs, Folkert W , Casas, Juan-Pablo, Keating, Brendan J, Preiss, David , Hingorani, Aroon D and Sattar, Naveed (2017) PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study. The Lancet Diabetes & Endocrinology 5 (2), pp. 97-105.

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Other URL: http://doi.org/10.1016/S2213-8587(16)30396-5


Abstract

Background Statin treatment and variants in the gene encoding HMG-CoA reductase are associated with reductions in both the concentration of LDL cholesterol and the risk of coronary heart disease, but also with modest hyperglycaemia, increased bodyweight, and modestly increased risk of type 2 diabetes, which in no way off sets their substantial benefi ts. We sought to investigate the associations ...

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Item type:Article
Date:2017
Institutions:Medicine > Institut für Epidemiologie und Präventivmedizin
Identification Number:
ValueType
10.1016/S2213-8587(16)30396-5DOI
Keywords:STATIN THERAPY; HEART-DISEASE; ASSOCIATION; HYPERCHOLESTEROLEMIA; METAANALYSIS; CHOLESTEROL; COMMON; ARCHITECTURE; PATHWAYS; INSIGHTS;
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38761
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