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Sex-specific association between functional neuropeptide S receptor gene (NPSR1) variants and cortisol and central stress responses

Streit, Fabian ; Akdeniz, Ceren ; Haddad, Leila ; Kumsta, Robert ; Entringer, Sonja ; Frank, Josef ; Yim, Ilona S. ; Zänkert, Sandra ; Witt, Stephanie H. ; Kirsch, Peter ; Rietschel, Marcella ; Wüst, Stefan



Abstract

The brain neuropeptide S (NPS) system has recently generated substantial interest and may be of major relevance for central stress regulation. The NPS receptor (NPSR1) is highly expressed in the limbic system, exogenous NPS exerts pronounced anxiolytic and fear-attenuating effects in rodents and extensive close crosstalk between the NPS system and the hypothalamic-pituitary-adrenal (HPA) axis has ...

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