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Macrophage-Derived Chemokine: A Putative Marker of Pharmacological Therapy Response in Major Depression?

Milenkovic, Vladimir M. ; Sarubin, Nina ; Hilbert, Sven ; Baghai, Thomas C. ; Stöffler, Friederike ; Lima-Ojeda, Juan M. ; Manook, André ; Almeqbaali, Khalifa ; Wetzel, Christian H. ; Rupprecht, Rainer ; Nothdurfter, Caroline



Abstract

Introduction: Inflammatory processes play an important and complex role in the pathophysiology of major depressive disorder (MDD), but, so far, no specific investigation of chemokines exists. Methods: In this study, we investigated the changes of plasma chemokine levels (eotaxin-1, eotaxin-3, IP-10, MCP-1, MCP-4, MDC, MIP-1 alpha, MIP-1 beta, and TARC) in 47 MDD patients before (PRE) and after 1 ...

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