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Disruption of the UBF gene induces aberrant somatic nucleolar bodies and disrupts embryo nucleolar precursor bodies

Hamdane, Nourdine ; Tremblay, Michel G. ; Dillinger, Stefan ; Stefanovsky, Victor Y. ; Németh, Attila ; Moss, Tom



Abstract

The nucleolus is the site of ribosome biogenesis and forms around the actively transcribed ribosomal RNA (rRNA) genes. However, the nucleolus is also implicated in cell cycle regulation, tumour suppression and chromosome segregation and nucleolar disfunction is linked to a wide range of human diseases. Interestingly, the nucleolus is also required for genome reprogramming and the establishment of ...

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