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Disruption of the UBF gene induces aberrant somatic nucleolar bodies and disrupts embryo nucleolar precursor bodies

Hamdane, Nourdine, Tremblay, Michel G., Dillinger, Stefan, Stefanovsky, Victor Y., Németh, Attila and Moss, Tom (2017) Disruption of the UBF gene induces aberrant somatic nucleolar bodies and disrupts embryo nucleolar precursor bodies. Gene 612, pp. 5-11.

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Other URL: http://doi.org/10.1016/j.gene.2016.09.013


Abstract

The nucleolus is the site of ribosome biogenesis and forms around the actively transcribed ribosomal RNA (rRNA) genes. However, the nucleolus is also implicated in cell cycle regulation, tumour suppression and chromosome segregation and nucleolar disfunction is linked to a wide range of human diseases. Interestingly, the nucleolus is also required for genome reprogramming and the establishment of ...

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Item type:Article
Date:2017
Institutions:Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie III
Identification Number:
ValueType
10.1016/j.gene.2016.09.013DOI
Keywords:PREIMPLANTATION MOUSE EMBRYOS; POLYMERASE-I TRANSCRIPTION; FACTOR TTF-I; RIBOSOME BIOGENESIS; MATERNAL NUCLEOLUS; RNA; LOCALIZATION; ORGANIZATION; MAMMALS; OOCYTES; Upstream Binding Factor (UBF/UBTF); Gene inactivation; Ribosome Biogenesis; Ribosomal RNA (rRNA) genes; Nucleolus; Nucleolar Precursor Body (NPB); Mouse cleavage embryos
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38999
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