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Microbiota Disruption Induced by Early Use of Broad-Spectrum Antibiotics Is an Independent Risk Factor of Outcome after Allogeneic Stem Cell Transplantation

Weber, Daniela ; Jenq, Robert R. ; Peled, Jonathan U. ; Taur, Ying ; Hiergeist, Andreas ; Koestler, Josef ; Dettmer, Katja ; Weber, Markus ; Wolff, Daniel ; Hahn, Joachim ; Pamer, Eric G. ; Herr, Wolfgang ; Gessner, André ; Oefner, Peter J. ; van den Brink, Marcel R. M. ; Holler, Ernst


In allogeneic stem cell transplantation (ASCT), systemic broad-spectrum antibiotics are frequently used for treatment of infectious complications, but their effect on microbiota composition is still poorly understood. This retrospective analysis of 621 patients who underwent ASCT at the University Medical Center of Regensburg and Memorial Sloan Kettering Cancer Center in New York assessed the ...


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