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A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis

Treiber, Thomas, Treiber, Nora, Plessmann, Uwe, Harlander, Simone, Daiß, Julia-Lisa, Eichner, Norbert, Lehmann, Gerhard, Schall, Kevin, Urlaub, Henning and Meister, Gunter (2017) A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis. Molecular Cell 66 (2), 270-284.e13.

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Other URL: http://doi.org/10.1016/j.molcel.2017.03.014


Abstract

During microRNA (miRNA) biogenesis, two endonucleolytic reactions convert stem-loop-structured precursors into mature miRNAs. These processing steps can be posttranscriptionally regulated by RNA-binding proteins (RBPs). Here, we have used a proteomics-based pull-down approach to map and characterize the interactome of a multitude of pre-miRNAs. We identify similar to 180 RBPs that interact ...

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Item type:Article
Date:2017
Institutions:Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie
Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie I > Prof. Dr. Gunter Meister
Identification Number:
ValueType
10.1016/j.molcel.2017.03.014DOI
Keywords:SEQUENCE DETERMINANTS; LIN28-LET-7 PATHWAY; SECONDARY STRUCTURE; GENE-REGULATION; PRE-MICRORNA; HNRNP A1; URIDYLATION; RECOGNITION; DROSOPHILA; TARGET;
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39084
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