Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults

Edwards, Todd L., Graff, Mariaelisa, Scott, Robert A., Justice, Anne E. , Young, Kristin L., Feitosa, Mary F., Barata, Llilda , Winkler, Thomas W., Chu, Audrey Y. , Mahajan, Anubha, Hadley, David, Xue, Luting , Workalemahu, Tsegaselassie , Heard-Costa, Nancy L., den Hoed, Marcel, Ahluwalia, Tarunveer S., Qi, Qibin, Ngwa, Julius S., Renström, Frida, Quaye, Lydia, Eicher, John D., Hayes, James E., Cornelis, Marilyn, Kutalik, Zoltan, Lim, Elise, Luan, Jian’an, Huffman, Jennifer E., Zhang, Weihua, Zhao, Wei, Griffin, Paula J., Haller, Toomas, Ahmad, Shafqat, Marques-Vidal, Pedro M., Bien, Stephanie, Yengo, Loic, Teumer, Alexander , Smith, Albert Vernon, Kumari, Meena, Harder, Marie Neergaard , Justesen, Johanne Marie, Kleber, Marcus E. , Hollensted, Mette, Lohman, Kurt , Rivera, Natalia V., Whitfield, John B., Zhao, Jing Hua, Stringham, Heather M., Lyytikäinen, Leo-Pekka, Huppertz, Charlotte, Willemsen, Gonneke, Peyrot, Wouter J., Wu, Ying, Kristiansson, Kati, Demirkan, Ayse, Fornage, Myriam, Hassinen, Maija, Bielak, Lawrence F., Cadby, Gemma, Tanaka, Toshiko, Mägi, Reedik, van der Most, Peter J., Jackson, Anne U., Bragg-Gresham, Jennifer L., Vitart, Veronique , Marten, Jonathan, Navarro, Pau, Bellis, Claire, Pasko, Dorota , Johansson, Åsa, Snitker, Søren, Cheng, Yu-Ching, Eriksson, Joel, Lim, Unhee , Aadahl, Mette, Adair, Linda S. , Amin, Najaf, Balkau, Beverley, Auvinen, Juha , Beilby, John, Bergman, Richard N., Bergmann, Sven , Bertoni, Alain G., Blangero, John , Bonnefond, Amélie, Bonnycastle, Lori L., Borja, Judith B., Brage, Søren, Busonero, Fabio , Buyske, Steve, Campbell, Harry, Chines, Peter S., Collins, Francis S., Corre, Tanguy , Smith, George Davey, Delgado, Graciela E., Dueker, Nicole, Dörr, Marcus, Ebeling, Tapani, Eiriksdottir, Gudny, Esko, Tõnu , Faul, Jessica D., Fu, Mao , Færch, Kristine, Gieger, Christian, Gläser, Sven, Gong, Jian, Gordon-Larsen, Penny, Grallert, Harald, Grammer, Tanja B. , Grarup, Niels, van Grootheest, Gerard, Harald, Kennet, Hastie, Nicholas D., Havulinna, Aki S., Hernandez, Dena, Hindorff, Lucia, Hocking, Lynne J., Holmens, Oddgeir L., Holzapfel, Christina, Hottenga, Jouke Jan, Huang, Jie, Huang, Tao, Hui, Jennie , Huth, Cornelia, Hutri-Kähönen, Nina, James, Alan L., Jansson, John-Olov, Jhun, Min A. , Juonala, Markus, Kinnunen, Leena, Koistinen, Heikki A. , Kolcic, Ivana, Komulainen, Pirjo, Kuusisto, Johanna, Kvaløy, Kirsti , Kähönen, Mika, Lakka, Timo A., Launer, Lenore J., Lehne, Benjamin, Lindgren, Cecilia M., Lorentzon, Mattias , Luben, Robert, Marre, Michel, Milaneschi, Yuri, Monda, Keri L. , Montgomery, Grant W., De Moor, Marleen H. M. , Mulas, Antonella, Müller-Nurasyid, Martina, Musk, A. W., Männikkö, Reija, Männistö, Satu, Narisu, Narisu, Nauck, Matthias, Nettleton, Jennifer A., Nolte, Ilja M., Oldehinkel, Albertine J., Olden, Matthias, Ong, Ken K., Padmanabhan, Sandosh, Paternoster, Lavinia, Perez, Jeremiah, Perola, Markus , Peters, Annette , Peters, Ulrike, Peyser, Patricia A. , Prokopenko, Inga, Puolijoki, Hannu, Raitakari, Olli T., Rankinen, Tuomo, Rasmussen-Torvik, Laura J., Rawal, Rajesh, Ridker, Paul M., Rose, Lynda M., Rudan, Igor, Sarti, Cinzia, Sarzynski, Mark A., Savonen, Kai, Scott, William R., Sanna, Serena, Shuldiner, Alan R., Sidney, Steve, Silbernagel, Günther , Smith, Blair H. , Smith, Jennifer A., Snieder, Harold, Stančáková, Alena, Sternfeld, Barbara, Swift, Amy J., Tammelin, Tuija, Tan, Sian-Tsung , Thorand, Barbara, Thuillier, Dorothée, Vandenput, Liesbeth , Vestergaard, Henrik , van Vliet-Ostaptchouk, Jana V. , Vohl, Marie-Claude, Völker, Uwe, Waeber, Gérard, Walker, Mark, Wild, Sarah , Wong, Andrew, Wright, Alan F., Zillikens, M. Carola, Zubair, Niha, Haiman, Christopher A., Lemarchand, Loic, Gyllensten, Ulf, Ohlsson, Claes, Hofman, Albert, Rivadeneira, Fernando, Uitterlinden, André G., Pérusse, Louis , Wilson, James F. , Hayward, Caroline, Polasek, Ozren , Cucca, Francesco, Hveem, Kristian, Hartman, Catharina A., Tönjes, Anke, Bandinelli, Stefania, Palmer, Lyle J. , Kardia, Sharon L. R., Rauramaa, Rainer, Sørensen, Thorkild I. A., Tuomilehto, Jaakko, Salomaa, Veikko, Penninx, Brenda W. J. H., de Geus, Eco J. C. , Boomsma, Dorret I., Lehtimäki, Terho, Mangino, Massimo, Laakso, Markku, Bouchard, Claude , Martin, Nicholas G., Kuh, Diana, Liu, Yongmei, Linneberg, Allan , März, Winfried, Strauch, Konstantin, Kivimäki, Mika , Harris, Tamara B., Gudnason, Vilmundur, Völzke, Henry, Qi, Lu, Järvelin, Marjo-Riitta, Chambers, John C., Kooner, Jaspal S., Froguel, Philippe, Kooperberg, Charles, Vollenweider, Peter, Hallmans, Göran, Hansen, Torben , Pedersen, Oluf , Metspalu, Andres, Wareham, Nicholas J., Langenberg, Claudia, Weir, David R., Porteous, David J., Boerwinkle, Eric, Chasman, Daniel I., Abecasis, Gonçalo R., Barroso, Inês, McCarthy, Mark I., Frayling, Timothy M., O’Connell, Jeffrey R., van Duijn, Cornelia M., Boehnke, Michael, Heid, Iris M., Mohlke, Karen L., Strachan, David P., Fox, Caroline S., Liu, Ching-Ti, Hirschhorn, Joel N., Klein, Robert J., Johnson, Andrew D., Borecki, Ingrid B., Franks, Paul W. , North, Kari E., Cupples, L. Adrienne, Loos, Ruth J. F. and Kilpeläinen, Tuomas O. (2017) Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults. PLOS Genetics 13 (4), e1006528.

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Other URL: http://doi.org/10.1371/journal.pgen.1006528

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Abstract

Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it ...

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