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Journal or Publication Title: | PLOS Genetics | ||||
Publisher: | PUBLIC LIBRARY SCIENCE | ||||
Place of Publication: | SAN FRANCISCO | ||||
Volume: | 13 | ||||
Number of Issue or Book Chapter: | 4 | ||||
Page Range: | e1006528 | ||||
Date: | 2017 | ||||
Institutions: | Medicine > Institut für Epidemiologie und Präventivmedizin > Lehrstuhl für Genetische Epidemiologie | ||||
Identification Number: |
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Keywords: | BODY-MASS INDEX; REACTIVE PROTEIN-LEVELS; GENE-EXPRESSION; IDENTICAL-TWINS; ADIPOCYTE DIFFERENTIATION; ASSOCIATION METAANALYSIS; ACTIVITY QUESTIONNAIRES; FAT DISTRIBUTION; BINDING PROTEIN; FOOD-INTAKE; | ||||
Dewey Decimal Classification: | 600 Technology > 610 Medical sciences Medicine | ||||
Status: | Published | ||||
Refereed: | Yes, this version has been refereed | ||||
Created at the University of Regensburg: | Yes | ||||
Item ID: | 39102 |

Abstract
Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it ...

Abstract
Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by similar to 30% in physically active individuals compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery.
Metadata last modified: 25 Nov 2020 15:45