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Genetic Contribution to Alcohol Dependence: Investigation of a Heterogeneous German Sample of Individuals with Alcohol Dependence, Chronic Alcoholic Pancreatitis, and Alcohol-Related Cirrhosis

Treutlein, Jens ; Frank, Josef ; Streit, Fabian ; Reinbold, Céline ; Juraeva, Dilafruz ; Degenhardt, Franziska ; Rietschel, Liz ; Witt, Stephanie ; Forstner, Andreas ; Ridinger, Monika ; Strohmaier, Jana ; Wodarz, Norbert ; Dukal, Helene ; Foo, Jerome ; Hoffmann, Per ; Herms, Stefan ; Heilmann-Heimbach, Stefanie ; Soyka, Michael ; Maier, Wolfgang ; Gaebel, Wolfgang ; Dahmen, Norbert ; Scherbaum, Norbert ; Müller-Myhsok, Bertram ; Lucae, Susanne ; Ising, Marcus ; Stickel, Felix ; Berg, Thomas ; Roggenbuck, Ulla ; Jöckel, Karl-Heinz ; Scholz, Henrike ; Zimmermann, Ulrich ; Buch, Stephan ; Sommer, Wolfgang ; Spanagel, Rainer ; Brors, Benedikt ; Cichon, Sven ; Mann, Karl ; Kiefer, Falk ; Hampe, Jochen ; Rosendahl, Jonas ; Nöthen, Markus ; Rietschel, Marcella



Abstract

The present study investigated the genetic contribution to alcohol dependence (AD) using genome-wide association data from three German samples. These comprised patients with: (i) AD; (ii) chronic alcoholic pancreatitis (ACP); and (iii) alcohol-related liver cirrhosis (ALC). Single marker, gene-based, and pathway analyses were conducted. A significant association was detected for the ADH1B locus ...

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