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Genetic Contribution to Alcohol Dependence: Investigation of a Heterogeneous German Sample of Individuals with Alcohol Dependence, Chronic Alcoholic Pancreatitis, and Alcohol-Related Cirrhosis

Treutlein, Jens, Frank, Josef, Streit, Fabian, Reinbold, Céline, Juraeva, Dilafruz, Degenhardt, Franziska, Rietschel, Liz, Witt, Stephanie , Forstner, Andreas, Ridinger, Monika, Strohmaier, Jana , Wodarz, Norbert, Dukal, Helene, Foo, Jerome , Hoffmann, Per , Herms, Stefan , Heilmann-Heimbach, Stefanie , Soyka, Michael, Maier, Wolfgang, Gaebel, Wolfgang, Dahmen, Norbert, Scherbaum, Norbert, Müller-Myhsok, Bertram, Lucae, Susanne, Ising, Marcus, Stickel, Felix, Berg, Thomas, Roggenbuck, Ulla, Jöckel, Karl-Heinz, Scholz, Henrike, Zimmermann, Ulrich, Buch, Stephan, Sommer, Wolfgang , Spanagel, Rainer, Brors, Benedikt , Cichon, Sven, Mann, Karl, Kiefer, Falk, Hampe, Jochen , Rosendahl, Jonas, Nöthen, Markus and Rietschel, Marcella (2017) Genetic Contribution to Alcohol Dependence: Investigation of a Heterogeneous German Sample of Individuals with Alcohol Dependence, Chronic Alcoholic Pancreatitis, and Alcohol-Related Cirrhosis. Genes 8 (7), p. 183.

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Other URL: http://doi.org/10.3390/genes8070183

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Abstract

The present study investigated the genetic contribution to alcohol dependence (AD) using genome-wide association data from three German samples. These comprised patients with: (i) AD; (ii) chronic alcoholic pancreatitis (ACP); and (iii) alcohol-related liver cirrhosis (ALC). Single marker, gene-based, and pathway analyses were conducted. A significant association was detected for the ADH1B locus ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Psychiatrie und Psychotherapie
Identification Number:
ValueType
10.3390/genes8070183DOI
Keywords:GENOME-WIDE ASSOCIATION; ALDEHYDE DEHYDROGENASE; EUROPEAN-AMERICANS; MAXIMUM NUMBER; LIVER-DISEASE; ADH1C GENE; RISK LOCI; POLYMORPHISMS; METAANALYSIS; METABOLISM; alcohol dependence; chronic alcoholic pancreatitis; alcoholic liver cirrhosis; genome-wide association study; alcohol dehydrogenase; ADH1B; ADH1C
Dewey Decimal Classification:100 Philosophy & psychology > 150 Psychology
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39385
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