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Conserved asymmetry underpins homodimerization of Dicer-associated double-stranded RNA-binding proteins

Heyam, Alex , Coupland, Claire E., Dégut, Clément, Haley, Ruth A., Baxter, Nicola J., Jakob, Leonhard, Aguiar, Pedro M. , Meister, Gunter, Williamson, Michael P., Lagos, Dimitris and Plevin, Michael J. (2017) Conserved asymmetry underpins homodimerization of Dicer-associated double-stranded RNA-binding proteins. Nucleic Acids Research 45 (21), pp. 12577-12584.

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Other URL: http://doi.org/10.1093/nar/gkx928

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Abstract

Double-stranded RNA-binding domains (dsRBDs) are commonly found in modular proteins that interact with RNA. Two varieties of dsRBD exist: canonical Type A dsRBDs interact with dsRNA, while non-canonical Type B dsRBDs lack RNA-binding residues and instead interact with other proteins. In higher eukaryotes, the microRNA biogenesis enzyme Dicer forms a 1:1 association with a dsRNA-binding protein ...

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Item type:Article
Date:2017
Institutions:Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie I > Prof. Dr. Gunter Meister
Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Mikrobiologie
Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Mikrobiologie > Prof. Dr. Dina Grohmann
Identification Number:
ValueType
10.1093/nar/gkx928DOI
Keywords:MICRORNA BIOGENESIS; KINASE PKR; HUMAN TRBP; DOMAIN; PACT; ACTIVATION; COMPLEXES; INTERACTS; SYMMETRY; MODEL;
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39508
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