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TSPO PET for glioma imaging using the novel ligand 18F-GE-180: first results in patients with glioblastoma

Albert, Nathalie L. ; Unterrainer, M. ; Fleischmann, D. F. ; Lindner, S. ; Vettermann, F. ; Brunegraf, A. ; Vomacka, L. ; Brendel, M. ; Wenter, V. ; Wetzel, C. ; Rupprecht, R. ; Tonn, J.-C. ; Belka, C. ; Bartenstein, P. ; Niyazi, M.


Objective The 18-kDa mitochondrial translocator protein (TSPO) was reported to be upregulated in gliomas. F-18-GE-180 is a novel 3rd generation TSPO receptor ligand with improved target-to-background contrast compared to previous tracers. In this pilot study, we compared PET imaging with F-18-GE-180 and MRI of patients with untreated and recurrent pretreated glioblastoma. Methods Eleven patients ...


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