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Distinct functions of Crumbs regulating slit diaphragms and endocytosis in Drosophila nephrocytes

Hochapfel, Florian ; Denk, Lucia ; Mendl, Gudrun ; Schulze, Ulf ; Maaßen, Christine ; Zaytseva, Yulia ; Pavenstädt, Hermann ; Weide, Thomas ; Rachel, Reinhard ; Witzgall, Ralph ; Krahn, Michael P.


Mammalian podocytes, the key determinants of the kidney's filtration barrier, differentiate from columnar epithelial cells and several key determinants of apical-basal polarity in the conventional epithelia have been shown to regulate podocyte morphogenesis and function. However, little is known about the role of Crumbs, a conserved polarity regulator in many epithelia, for slit-diaphragm ...


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