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Distinct functions of Crumbs regulating slit diaphragms and endocytosis in Drosophila nephrocytes

Hochapfel, Florian, Denk, Lucia, Mendl, Gudrun, Schulze, Ulf, Maaßen, Christine, Zaytseva, Yulia, Pavenstädt, Hermann, Weide, Thomas, Rachel, Reinhard, Witzgall, Ralph and Krahn, Michael P. (2017) Distinct functions of Crumbs regulating slit diaphragms and endocytosis in Drosophila nephrocytes. Cellular and Molecular Life Sciences 74 (24), pp. 4573-4586.

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Other URL: http://doi.org/10.1007/s00018-017-2593-y


Abstract

Mammalian podocytes, the key determinants of the kidney's filtration barrier, differentiate from columnar epithelial cells and several key determinants of apical-basal polarity in the conventional epithelia have been shown to regulate podocyte morphogenesis and function. However, little is known about the role of Crumbs, a conserved polarity regulator in many epithelia, for slit-diaphragm ...

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Item type:Article
Date:2017
Institutions:Biology, Preclinical Medicine > Institut für Anatomie > Lehrstuhl für Molekulare und zelluläre Anatomie
Identification Number:
ValueType
10.1007/s00018-017-2593-yDOI
Keywords:MAMMALIAN EPITHELIAL-CELLS; ZONULA ADHERENS FORMATION; TIGHT JUNCTION PROTEIN; APICAL MEMBRANE; PHOTORECEPTOR MORPHOGENESIS; NEPHROTIC SYNDROME; APKC-LAMBDA/IOTA; POLARITY DEFECTS; COMPLEX; MOESIN; Nephrocyte; Podocyte; Crumbs; Moesin; Slit diaphragm; Endocytosis
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39546
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