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Hair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes

Rietschel, Liz ; Streit, Fabian ; Zhu, Gu ; McAloney, Kerrie ; Frank, Josef ; Couvy-Duchesne, Baptiste ; Witt, Stephanie H. ; Binz, Tina M. ; McGrath, John ; Hickie, Ian B. ; Hansell, Narelle K. ; Wright, Margaret J. ; Gillespie, Nathan A. ; Forstner, Andreas J. ; Schulze, Thomas G. ; Wüst, Stefan ; Nöthen, Markus M. ; Baumgartner, Markus R. ; Walker, Brian R. ; Crawford, Andrew A. ; Colodro-Conde, Lucía ; Medland, Sarah E. ; Martin, Nicholas G. ; Rietschel, Marcella



Abstract

Hair cortisol concentration (HCC) is a promising measure of long-term hypothalamus-pituitary-adrenal (HPA) axis activity. Previous research has suggested an association between HCC and psychological variables, and initial studies of inter-individual variance in HCC have implicated genetic factors. However, whether HCC and psychological variables share genetic risk factors remains unclear. The ...

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