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HSP90 is necessary for the ACK1-dependent phosphorylation of STAT1 and STAT3

Mahendrarajah, Nisintha ; Borisova, Marina E. ; Reichardt, Sigrid ; Godmann, Maren ; Sellmer, Andreas ; Mahboobi, Siavosh ; Haitel, Andrea ; Schmid, Katharina ; Kenner, Lukas ; Heinzel, Thorsten ; Beli, Petra ; Krämer, Oliver H.



Abstract

Signal transducers and activators of transcription (STATs) are latent, cytoplasmic transcription factors. Janus kinases (JAKs) and activated CDC42-associated kinase-1 (ACK1/TNK2) catalyse the phosphorylation of STAT1 and the expression of its target genes. Here we demonstrate that catalytically active ACK1 promotes the phosphorylation and nuclear accumulation of STAT1 in transformed kidney cells. ...

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