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TSPO imaging using the novel PET ligand [18F]GE-180: quantification approaches in patients with multiple sclerosis

Vomacka, Lena ; Albert, Nathalie Lisa ; Lindner, Simon ; Unterrainer, Marcus ; Mahler, Christoph ; Brendel, Matthias ; Ermoschkin, Larissa ; Gosewisch, Astrid ; Brunegraf, Anika ; Buckley, Christopher ; Kümpfel, Tania ; Rupprecht, Rainer ; Ziegler, Sibylle ; Kerschensteiner, Martin ; Bartenstein, Peter ; Böning, Guido



Abstract

Background: PET ligands targeting the translocator protein (TSPO) represent promising tools to visualise neuroinflammation. Here, we analysed parameters obtained in dynamic and static PET images using the novel TSPO ligand [F-18]GE-180 in patients with relapsing remitting multiple sclerosis (RRMS) and an approach for semi-quantitative assessment of this disease in clinical routine. Seventeen ...

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