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Structural magnetic resonance imaging in amyotrophic lateral sclerosis: cortical morphometry, diffusion properties and lesion detection as potential biomarkers for the state and progression of amyotrophic lateral sclerosis

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Wirth, Anna Maria
License: Creative Commons Attribution Non-commercial 4.0
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Date of publication of this fulltext: 27 May 2019 12:20

Abstract (English)

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease primarily affecting the motor system of the central nervous system. The aim of this thesis is to evaluate the potential of structural magnetic resonance imaging (MRI) biomarkers of the brain grey matter (GM) and white matter (WM) for the state and progression of ALS. The thesis has been conducted on behalf of a ...


Translation of the abstract (German)

Amyotrophe Lateralsklerose (ALS) ist eine progressive neurodegenerative Erkrankung, die primär das motorische System des zentralen Nervensystems betrifft. Ziel dieser Abschlussarbeit ist die Evaluation des Potenzials von Biomarkern der grauen und weißen Substanz für das Stadium und den Verlauf der Amyotrophen Lateralsklerose mittels der strukturellen Magnetresonanztomographie (MRT). Die ...


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