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Influenza A virus mimetic nanoparticles trigger selective cell uptake

Maslanka-Figueroa, Sara, Veser, Anika, Abstiens, Kathrin, Fleischmann, Daniel and Göpferich, Achim (2019) Influenza A virus mimetic nanoparticles trigger selective cell uptake. PNAS 116 (20), pp. 9831-9836.

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Abstract

Poor target cell specificity is currently a major shortcoming of nanoparticles (NPs) used for biomedical applications. It causes significant material loss to off-target sites and poor availability at the intended delivery site. To overcome this limitation, we designed particles that identify cells in a virus-like manner. As a blueprint, we chose a mechanism typical of influenza A virus particles ...

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Item type:Article
Date:2019
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich)
Identification Number:
ValueType
31036631PubMed ID
10.1073/pnas.1902563116DOI
Keywords:virus-mimetic nanoparticles; influenza A; heteromultivalent; target specific; enzyme responsive
Dewey Decimal Classification:600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:40218
Owner only: item control page
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