Neumann, K., Arzt, M., Heid, I., Böger, C. and Stadler, S.
(2019)
Sleep-Disordered Breathing Is Associated with Metabolic Syndrome in Outpatients with Diabetes Mellitus Type 2.
Journal of Diabetes Research 2019, pp. 1-11.
Date of publication of this fulltext: 03 Jul 2019 14:58at publisher (via DOI)
Other URL: http://doi.org/10.1155/2019/8417575
Abstract
Background. Metabolic syndrome (MS) and sleep-disordered breathing (SDB) are highly prevalent in patients with diabetes mellitus type 2 (DM2). The present study examined whether there is an independent association between SDB and MS in a sample of outpatients with DM2. Methods. MS was determined in 679 patients of the DIACORE-SDB substudy, a study of outpatients with DM2. According to the ...
Abstract
Background. Metabolic syndrome (MS) and sleep-disordered breathing (SDB) are highly prevalent in patients with diabetes mellitus type 2 (DM2). The present study examined whether there is an independent association between SDB and MS in a sample of outpatients with DM2. Methods. MS was determined in 679 patients of the DIACORE-SDB substudy, a study of outpatients with DM2. According to the National Cholesterol Education Program (NCEP) criteria, MS is defined by at least three of the following five criteria: waist circumference of >102 cm (men)/>88 cm (women), blood pressure of ≥130/85 mmHg, a fasting triglyceride level of >150 mg/dl, high-density lipoprotein (HDL) of <40 mg/dl (men)/<50 mg/dl (women), and a fasting glucose level of ≥110 mg/dl. The apnea-hypopnea index (AHI) was assessed with a 2-channel ambulatory monitoring device and used to define the severity of SDB (: no/mild SDB; AHI 15.0-29.9: moderate SDB; : severe SDB). Results. 228 (34%) of the 679 participants (mean age 66 years, mean body mass index (BMI) 31.2 kg/m2, and mean AHI 14/hour) had SDB. MS was significantly more frequent in patients with more severe SDB (no/mild SDB vs. moderate SDB vs. severe SDB: 72% vs. 79% vs. 85%, respectively, ). Logistic regression analysis adjusted for sex, age, obesity ( kg/m2), and the HOMA index showed a significant association between the AHI and the presence of MS (OR (1.011; 1.068); ). Further, male sex, obesity, and the HOMA index were significantly associated with MS. Conclusion. SDB is significantly and independently associated with MS in outpatients with DM2.
Export bibliographical data
Download Statistics