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- URN zum Zitieren dieses Dokuments:
- urn:nbn:de:bvb:355-epub-404431
- DOI zum Zitieren dieses Dokuments:
- 10.5283/epub.40443
Zusammenfassung
D-2-Hydroxyglutarate (D-2-HG) is regarded as an oncometabolite. It is found at elevated levels in certain malignancies such as acute myeloid leukaemia and glioma. It is produced by a mutated isocitrate dehydrogenase IDH1/2, a low-affinity/high-capacity enzyme. Its degradation, in contrast, is catalysed by the high-affinity/low-capacity enzyme D-2-hydroxyglutarate dehydrogenase (D2HDH). So far, it ...
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