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Conformational proofreading of distant 40S ribosomal subunit maturation events by a long-range communication mechanism

Mitterer, Valentin, Shayan, Ramtin, Ferreira-Cerca, Sébastien, Murat, Guillaume, Enne, Tanja, Rinaldi, Dana, Weigl, Sarah, Omanic, Hajrija, Gleizes, Pierre-Emmanuel, Kressler, Dieter, Plisson-Chastang, Celia and Pertschy, Brigitte (2019) Conformational proofreading of distant 40S ribosomal subunit maturation events by a long-range communication mechanism. Nature Communications 10 (1), pp. 1-15.

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Date of publication of this fulltext: 04 Jul 2019 05:30

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Other URL: http://doi.org/10.1038/s41467-019-10678-z


Abstract

Eukaryotic ribosomes are synthesized in a hierarchical process driven by a plethora of assembly factors, but how maturation events at physically distant sites on pre-ribosomes are coordinated is poorly understood. Using functional analyses and cryo-EM, we show that ribosomal protein Rps20 orchestrates communication between two multi-step maturation events across the pre-40S subunit. Our study ...

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Item type:Article
Date:21 June 2019
Institutions:Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie III
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1038/s41467-019-10678-zDOI
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:40455
Owner only: item control page

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