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Conformational proofreading of distant 40S ribosomal subunit maturation events by a long-range communication mechanism

URN to cite this document:
urn:nbn:de:bvb:355-epub-404559
DOI to cite this document:
10.5283/epub.40455
Mitterer, Valentin ; Shayan, Ramtin ; Ferreira-Cerca, Sébastien ; Murat, Guillaume ; Enne, Tanja ; Rinaldi, Dana ; Weigl, Sarah ; Omanic, Hajrija ; Gleizes, Pierre-Emmanuel ; Kressler, Dieter ; Plisson-Chastang, Celia ; Pertschy, Brigitte
Date of publication of this fulltext: 04 Jul 2019 05:30


Abstract

Eukaryotic ribosomes are synthesized in a hierarchical process driven by a plethora of assembly factors, but how maturation events at physically distant sites on pre-ribosomes are coordinated is poorly understood. Using functional analyses and cryo-EM, we show that ribosomal protein Rps20 orchestrates communication between two multi-step maturation events across the pre-40S subunit. Our study ...

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