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Repeated determination of moxifloxacin concentrations in interstitial space fluid of muscle and subcutis in septic patients

Nowak, Hartmuth ; Weidemann, Caroline ; Martini, Stefan ; Oesterreicher, Zoe Anne ; Dorn, Christoph ; Adamzik, Michael ; Kees, Frieder ; Zeitlinger, Markus ; Rahmel, Tim


BACKGROUND: For an effective antimicrobial treatment, it is crucial that antibiotics reach sufficient concentrations in plasma and tissue. Currently no data exist regarding moxifloxacin plasma concentrations and exposure levels in tissue under septic conditions. OBJECTIVES: To determine the pharmacokinetics of moxifloxacin in plasma and interstitial space fluid over a prolonged ...


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