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Hydrogel microspheres evading alveolar macrophages for sustained pulmonary protein delivery

Graf, Moritz, Ziegler, Christian, Gregoritza, Manuel and Goepferich, Achim (2019) Hydrogel microspheres evading alveolar macrophages for sustained pulmonary protein delivery. nternational Journal of Pharmaceutics 566, pp. 652-661.

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Other URL: https://doi.org/10.1016/j.ijpharm.2019.06.019


Abstract

Pulmonary delivery is a highly attractive alternative to injections for biologics such as therapeutic proteins. However, bioavailabilities generally suffer from the presence of phagocytic cells that clear particulate matter entering the lung. In this study, microgel particles were developed using an all-aqueous two-phase system approach and evaluated for their efficacy as an inhalable controlled ...

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Item type:Article
Date:2019
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich)
Identification Number:
ValueType
10.1016/j.ijpharm.2019.06.019DOI
Keywords:Aqueous two-phase system, Thiol-ene, Controlled release, Inhalation, Protein delivery, Hydrogel, Click chemistry
Dewey Decimal Classification:600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:40508
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