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Minocycline alters behavior, microglia and the gut microbiome in a trait-anxiety-dependent manner

Schmidtner, Anna K., Slattery, David A., Gläsner, Joachim, Hiergeist, Andreas, Gryksa, Katharina, Malik, Victoria A., Hellmann-Regen, Julian, Heuser, Isabella, Baghai, Thomas C., Gessner, André, Rupprecht, Rainer, Di Benedetto, Barbara and Neumann, Inga D. (2019) Minocycline alters behavior, microglia and the gut microbiome in a trait-anxiety-dependent manner. Translational Psychiatry 9 (1), p. 223.

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Date of publication of this fulltext: 18 Sep 2019 13:17

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Other URL: http://doi.org/10.1038/s41398-019-0556-9


Abstract

Major depressive disorder is the main cause of disability worldwide with imperfect treatment options. However, novel therapeutic approaches are currently discussed, from augmentation strategies to novel treatments targeting the immune system or the microbiome-gut-brain axis. Therefore, we examined the potential beneficial effects of minocycline, a tetracycline antibiotic with pleiotropic, ...

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Item type:Article
Date:13 September 2019
Institutions:Biology, Preclinical Medicine > Institut für Zoologie > Tierphysiologie/Neurobiologie (Prof. Dr. Inga Neumann)
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1038/s41398-019-0556-9DOI
Dewey Decimal Classification:500 Science > 590 Zoological sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:40720
Owner only: item control page

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