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Minocycline alters behavior, microglia and the gut microbiome in a trait-anxiety-dependent manner

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Schmidtner, Anna K. ; Slattery, David A. ; Gläsner, Joachim ; Hiergeist, Andreas ; Gryksa, Katharina ; Malik, Victoria A. ; Hellmann-Regen, Julian ; Heuser, Isabella ; Baghai, Thomas C. ; Gessner, André ; Rupprecht, Rainer ; Di Benedetto, Barbara ; Neumann, Inga D.
Date of publication of this fulltext: 18 Sep 2019 13:17


Major depressive disorder is the main cause of disability worldwide with imperfect treatment options. However, novel therapeutic approaches are currently discussed, from augmentation strategies to novel treatments targeting the immune system or the microbiome-gut-brain axis. Therefore, we examined the potential beneficial effects of minocycline, a tetracycline antibiotic with pleiotropic, ...


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