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Analysis of Allosteric Communication Pathways in Class I Glutamine Amidotransferases

URN to cite this document:
urn:nbn:de:bvb:355-epub-407227
DOI to cite this document:
10.5283/epub.40722
Semmelmannn, Florian
Date of publication of this fulltext: 24 Sep 2019 08:29


Abstract (English)

Class I glutamine amidotransferases (GATases) represent a ubiquitous family of enzymes that catalyze the incorporation of ammonia within various metabolic pathways. GATases are heteromeric enzyme complexes consisting of at least one pair of glutaminase and synthase subunits in various oligomeric associations. The activities of the glutaminase and synthase subunits are allosterically coupled in ...

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Translation of the abstract (German)

Klasse I Glutaminamidotransferasen (GATasen) repräsentieren eine weit verbreitete Enzymfamilie, die den Einbau von Ammoniak in einer Vielzahl metabolischer Pfade katalysieren. GATasen sind heteromere Enzymkomplexe, die aus mindestens einem Paar von Glutaminase- und Synthase-Untereinheiten in verschiedenen Oligomerisierungszuständen bestehen. Die Aktivitäten der Glutaminase- und ...

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