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Restricting Glycolysis Preserves T Cell Effector Functions and Augments Checkpoint Therapy

Renner, Kathrin, Bruss, Christina, Schnell, Annette, Koehl, Gudrun, Becker, Holger M., Fante, Matthias, Menevse, Ayse-Nur, Kauer, Nathalie, Blazquez, Raquel, Hacker, Lisa, Decking, Sonja-Maria, Bohn, Toszka, Faerber, Stephanie, Evert, Katja, Aigle, Lisa, Amslinger, Sabine, Landa, Maria, Krijgsman, Oscar, Rozeman, Elisa A., Brummer, Christina, Siska, Peter J., Singer, Katrin, Pektor, Stefanie, Miederer, Matthias, Peter, Katrin, Gottfried, Eva, Herr, Wolfgang, Marchiq, Ibtisam, Pouyssegur, Jacques, Roush, William R., Ong, SuFey, Warren, Sarah, Pukrop, Tobias, Beckhove, Philipp, Lang, Sven A., Bopp, Tobias, Blank, Christian U., Cleveland, John L., Oefner, Peter J., Dettmer, Katja, Selby, Mark and Kreutz, Marina (2019) Restricting Glycolysis Preserves T Cell Effector Functions and Augments Checkpoint Therapy. Cell Reports 29 (1), 135-150.e9.

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Date of publication of this fulltext: 10 Oct 2019 14:34

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Other URL: http://doi.org/10.1016/j.celrep.2019.08.068


Abstract

Tumor-derived lactic acid inhibits T and natural killer (NK) cell function and, thereby, tumor immunosurveillance. Here, we report that melanoma patients with high expression of glycolysis-related genes show a worse progression free survival upon anti-PD1 treatment. The non-steroidal anti-inflammatory drug (NSAID) diclofenac lowers lactate secretion of tumor cells and improves anti-PD1-induced T ...

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Item type:Article
Date:1 October 2019
Institutions:Medicine > Lehrstuhl für Chirurgie
Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Medicine > Lehrstuhl für Immunologie
Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Medicine > Lehrstuhl für Pathologie
Chemistry and Pharmacy > Institut für Organische Chemie
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1016/j.celrep.2019.08.068DOI
Keywords:checkpoint; glycolysis; monocarboxylate transporters; lactate; acidification; diclofenac; T cells; NK cells; interferon gamma; tumor
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:40812
Owner only: item control page

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