The contrast response functions (CRF) of pattern-appearance and motion-onset VEPs for periodic stimuli (gratings) were compared. The CRF for pattern-appearance is accelerative for the P100 component and compressive for the N200 component. Contrary to these results, the CRF for motion-onset shows an almost negligible slope for both components within the contrast range tested (0.5–64%). To better isolate the neural contributions to these different VEP components, we studied the effects of prior adaptation to stationary and moving gratings. Adaptation to stationary gratings has no effect on both VEP components for motion-onset and the P100 component for pattern-appearance, but did reduce the amplitude of the N200 for pattern-appearance. Adaptation to slow (1 deg/s) and fast (4 deg/s) gratings left the P100 amplitudes unaltered, while it significantly reduced the N200 amplitudes for both pattern-appearance and motion-onset. These results suggest that the N200 component of the motion-onset VEP is generated by motion-dependent neurons, whereas the same component for pattern-appearance arises from contrast-dependent neurons. The observed differences between P100 and N200 components appear to reflect the activity of both transient and sustained neural mechanisms