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High CD206 levels in Hodgkin lymphoma-educated macrophages are linked to matrix-remodeling and lymphoma dissemination

Arlt, A. ; von Bonin, F. ; Rehberg, Thorsten ; Perez-Rubio, Paula ; Engelmann, Julia C. ; Limm, Katharina ; Reinke, S. ; Dullin, C. ; Sun, Xueni ; Specht, R. ; Maulhardt, M. ; Linke, F. ; Bunt, G. ; Klapper, W. ; Vockerodt, M. ; Wilting, J. ; Pukrop, T. ; Dettmer, Katja ; Gronwald, Wolfram ; Oefner, Peter J. ; Spang, Rainer ; Kube, D.


Macrophages (M phi) are abundantly present in the tumor microenvironment and may predict outcome in solid tumors and defined lymphoma subtypes. M phi heterogeneity, the mechanisms of their recruitment, and their differentiation into lymphoma-promoting, alternatively activated M2-like phenotypes are still not fully understood. Therefore, further functional studies are required to understand ...


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