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High CD206 levels in Hodgkin lymphoma-educated macrophages are linked to matrix-remodeling and lymphoma dissemination

Arlt, A. ; von Bonin, F. ; Rehberg, Thorsten ; Perez-Rubio, Paula ; Engelmann, Julia C. ; Limm, Katharina ; Reinke, S. ; Dullin, C. ; Sun, Xueni ; Specht, R. ; Maulhardt, M. ; Linke, F. ; Bunt, G. ; Klapper, W. ; Vockerodt, M. ; Wilting, J. ; Pukrop, T. ; Dettmer, Katja ; Gronwald, Wolfram ; Oefner, Peter J. ; Spang, Rainer ; Kube, D.



Abstract

Macrophages (Mφ) are abundantly present in the tumor microenvironment and may predict outcome in solid tumors and defined lymphoma subtypes. Mφ heterogeneity, the mechanisms of their recruitment, and their differentiation into lymphoma-promoting, alternatively activated M2-like phenotypes are still not fully understood. Therefore, further functional studies are required to understand biological ...

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