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Presentation of HIV-1 Envelope Trimers on the Surface of Silicia Nanoparticles

Thalhauser, Stefanie ; Peterhoff, David ; Wagner, Ralf ; Breunig, Miriam



Abstract

Inducing immune responses protecting from HIV infection or at least controlling replication poses a huge challenge to modern vaccinology. An increasingly discussed strategy to elicit a potent and broad neutralizing antibody response is the immobilization of HIV’s trimeric envelope (Env) surface receptor on a nanoparticulate carrier. As a conceptual proof, we attached an Env variant (BG505 ...

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