Four-And-A-Half LIM-Domain Protein 2 (FHL2) Deficiency Aggravates Cholestatic Liver Injury

URN to cite this document:: urn:nbn:de:bvb:355-epub-414206
DOI to cite this document:: 10.5283/epub.41420

Sommer, Judith ; Dorn, Christoph

; Gäbele, Erwin ; Bataille, Frauke ; Freese, Kim ; Seitz, Tatjana ; Thasler, Wolfgang E. ; Büttner, Reinhard ; Weiskirchen, Ralf

; Bosserhoff, Anja

; Hellerbrand, Claus

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Date of publication of this fulltext: 27 Jan 2020 14:37

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Abstract

Cholestasis occurs in different clinical circumstances and leads to severe hepatic disorders. The four-and-a-half LIM-domain protein 2 (FHL2) is a scaffolding protein that modulates multiple signal transduction pathways in a tissue- and cell context-specific manner. In this study, we aimed to gain insight into the function of FHL2 in cholestatic liver injury. FHL2 expression was significantly ...