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Four-And-A-Half LIM-Domain Protein 2 (FHL2) Deficiency Aggravates Cholestatic Liver Injury

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Sommer, Judith ; Dorn, Christoph ; Gäbele, Erwin ; Bataille, Frauke ; Freese, Kim ; Seitz, Tatjana ; Thasler, Wolfgang E. ; Büttner, Reinhard ; Weiskirchen, Ralf ; Bosserhoff, Anja ; Hellerbrand, Claus
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 27 Jan 2020 14:37


Cholestasis occurs in different clinical circumstances and leads to severe hepatic disorders. The four-and-a-half LIM-domain protein 2 (FHL2) is a scaffolding protein that modulates multiple signal transduction pathways in a tissue- and cell context-specific manner. In this study, we aimed to gain insight into the function of FHL2 in cholestatic liver injury. FHL2 expression was significantly ...


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