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DTD: An R Package for Digital Tissue Deconvolution

Schoen, Marian ; Simeth, Jakob ; Heinrich, Paul ; Goertler, F. ; Solbrig, Stefan ; Wettig, Tilo ; Oefner, Peter J. ; Altenbuchinger, Michael ; Spang, Rainer



Abstract

Digital tissue deconvolution (DTD) estimates the cellular composition of a tissue from its bulk gene-expression profile. For this, DTD approximates the bulk as a mixture of cell-specific expression profiles. Different tissues have different cellular compositions, with cells in different activation states, and embedded in different environments. Consequently, DTD can profit from tailoring the ...

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