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Oxidative stress increased endogenous complement-dependent inflammatory and angiogenic responses in retinal pigment epithelial cells - independent from exogenous complement sources

URN to cite this document:
urn:nbn:de:bvb:355-epub-415936
DOI to cite this document:
10.5283/epub.41593
Trakkides, Timon-Orest ; Schäfer, Nicole ; Reichenthaler, Maria ; Kühn, Konstanze ; Urban, Florian ; Wegener, Joachim ; Pauly, Diana ; ; ;
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Date of publication of this fulltext: 13 Feb 2020 14:39


Abstract

Oxidative stress-induced damage of the retinal pigment epithelium (RPE) and chronic inflammation have been suggested as major contributors to a range of retinal diseases. Here, we examined the effects of oxidative stress on endogenous complement components and proinflammatory and angiogenic responses in RPE cells. ARPE-19 cells exposed for 1-48 h to H2O2 had reduced cell-cell contact and ...

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