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Oxidative stress increased endogenous complement-dependent inflammatory and angiogenic responses in retinal pigment epithelial cells - independent from exogenous complement sources

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Trakkides, Timon-Orest ; Schäfer, Nicole ; Reichenthaler, Maria ; Kühn, Konstanze ; Urban, Florian ; Wegener, Joachim ; Pauly, Diana ; ; ;
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 13 Feb 2020 14:39


Oxidative stress-induced damage of the retinal pigment epithelium (RPE) and chronic inflammation have been suggested as major contributors to a range of retinal diseases. Here, we examined the effects of oxidative stress on endogenous complement components and proinflammatory and angiogenic responses in RPE cells. ARPE-19 cells exposed for 1-48 h to H2O2 had reduced cell-cell contact and ...


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