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The Effect of Ligand Mobility on the Cellular Interaction of Multivalent Nanoparticles

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Maslanka-Figueroa, Sara ; Fleischmann, Daniel ; Beck, Sebastian ; Goepferich, Achim
Date of publication of this fulltext: 26 Feb 2020 08:50

This publication is part of the DEAL contract with Wiley.


Multivalent nanoparticle binding to cells can be of picomolar avidity making such interactions almost as intense as those seen with antibodies. However, reducing nanoparticle design exclusively to avidity optimization by the choice of ligand and its surface density does not sufficiently account for controlling and understanding cell-particle interactions. Cell uptake, for example, is of paramount ...


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