Zusammenfassung
A key link between amino acid catabolism and immune regulation in cancer is the augmented tryptophan (Trp) catabolism through the kynurenine pathway (KP), a metabolic route induced by interferon-gamma (IFN-gamma) and related to poor prognosis in melanomas. Besides its role in cancer, IFN-gamma plays a key role in the control of pigmentation homeostasis. Here we measured KP metabolites in human ...
Zusammenfassung
A key link between amino acid catabolism and immune regulation in cancer is the augmented tryptophan (Trp) catabolism through the kynurenine pathway (KP), a metabolic route induced by interferon-gamma (IFN-gamma) and related to poor prognosis in melanomas. Besides its role in cancer, IFN-gamma plays a key role in the control of pigmentation homeostasis. Here we measured KP metabolites in human melanoma lines and skin melanocytes and fibroblasts in response to IFN-gamma. In general, IFN-gamma affected KP in skin cells more than in melanoma cells, supporting IFN-gamma roles in skin physiology and that of stromal cells in modulating the tumor microenvironment.
Altmetric