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Pharmacological modulation of astrocytes and the role of cell type-specific histone modifications for the treatment of mood disorders

Jakovcevski, Mira ; Akbarian, Schahram ; Di Benedetto, Barbara



Abstract

Astrocytes orchestrate arrangement and functions of neuronal circuits and of the blood brain barrier. Dysfunctional astrocytes characterize mood disorders, here showcased by deregulation of the astrocyte end-feet protein Aquaporin-4 around blood vessels and, hypothetically, of the astrocyte-specific phagocytic protein MEGF10 to shape synapses. Development of mood disorders is often a result of ...

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