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Lead ions abrogate lipopolysaccharide-induced nitric monoxide toxicity by reducing the expression of STAT1 and iNOS

Dörpinghaus, Michael ; Brieger, Anne ; Panichkina, Olga ; Rink, Lothar ; Haase, Hajo



Abstract

Lead is a widespread environmental pollutant and the highly poisonous metal compromises multiple organs in the body. Among other tissues and cells, lead ions (Pb2+) can affect macrophages and microglia cells. The present study observed a concentration-dependent protection of BV-2 microglia and RAW 264.7 macrophages by Pb2+ against lipopolysaccharide (LPS)-induced toxicity. Both cell lines are ...

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