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Nioplexes encapsulated in supramolecular hybrid biohydrogels as versatile delivery platforms for nucleic acids

Grijalvo, Santiago ; Puras, Gustavo ; Zárate, Jon ; Pons, Ramon ; Pedraz, Jose Luis ; Eritja, Ramon ; Díaz, David Díaz


Supramolecular hydrogels based on N-protected phenylalanine (Fmoc-Phe-OH) were used to encapsulate non-ionic surfactant vesicles (niosomes). The niosomes consisted of an amphiphilic lipid mixed with polysorbate-80 and electrostatically complexed with a fluorescently labelled oligodeoxynucleotide (FITC-ODN) as a model nucleic acid derivative. The diffusion properties of the supramolecular hydrogel ...


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