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Subcortical brain alterations in major depressive disorder: findings from the ENIGMA Major Depressive Disorder working group

Schmaal, L ; Veltman, D J ; van Erp, T G M ; Sämann, P G ; Frodl, T ; Jahanshad, N ; Loehrer, E ; Tiemeier, H ; Hofman, A ; Niessen, W J ; Vernooij, M W ; Ikram, M A ; Wittfeld, K ; Grabe, H J ; Block, A ; Hegenscheid, K ; Völzke, H ; Hoehn, D ; Czisch, M ; Lagopoulos, J ; Hatton, S N ; Hickie, I B ; Goya-Maldonado, R ; Krämer, B ; Gruber, O ; Couvy-Duchesne, B ; Rentería, M E ; Strike, L T ; Mills, N T ; de Zubicaray, G I ; McMahon, K L ; Medland, S E ; Martin, N G ; Gillespie, N A ; Wright, M J ; Hall, G B ; MacQueen, G M ; Frey, E M ; Carballedo, A ; van Velzen, L S ; van Tol, M J ; van der Wee, N J ; Veer, I M ; Walter, H ; Schnell, K ; Schramm, E ; Normann, C ; Schoepf, D ; Konrad, C ; Zurowski, B ; Nickson, T ; McIntosh, A M ; Papmeyer, M ; Whalley, H C ; Sussmann, J E ; Godlewska, B R ; Cowen, P J ; Fischer, F H ; Rose, M ; Penninx, B W J H ; Thompson, P M ; Hibar, D P



Abstract

The pattern of structural brain alterations associated with major depressive disorder (MDD) remains unresolved. This is in part due to small sample sizes of neuroimaging studies resulting in limited statistical power, disease heterogeneity and the complex interactions between clinical characteristics and brain morphology. To address this, we meta-analyzed three-dimensional brain magnetic ...

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