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Converging evidence for an impact of a functionalNOSgene variation on anxiety-related processes

Kuhn, Manuel ; Haaker, Jan ; Glotzbach-Schoon, Evelyn ; Schümann, Dirk ; Andreatta, Marta ; Mechias, Marie-Luise ; Raczka, Karolina ; Gartmann, Nina ; Büchel, Christian ; Mühlberger, Andreas ; Pauli, Paul ; Reif, Andreas ; Kalisch, Raffael ; Lonsdorf, Tina B.



Abstract

Being a complex phenotype with substantial heritability, anxiety and related phenotypes are characterized by a complex polygenic basis. Thereby, one candidate pathway is neuronal nitric oxide (NO) signaling, and accordingly, rodent studies have identified NO synthase (NOS-I), encoded by NOS1, as a strong molecular candidate for modulating anxiety and hippocampus-dependent learning processes. ...

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