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Use of cardiac glycosides and risk of glioma

Seliger, Corinna ; Meier, Christoph R. ; Jick, Susan S. ; Uhl, Martin ; Bogdahn, Ulrich ; Hau, Peter ; Leitzmann, M. F.


Cardiac glycosides induce apoptotic effects on glioma cells, but whether cardiac glycosides protect against risk for glioma is unknown. We therefore explored the relation between glycoside use and glioma risk using a large and validated database. We performed a case-control analysis using the Clinical Practice Research Datalink involving 2005 glioma cases diagnosed between 1995 and 2012 that were ...


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