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Translocator Protein (TSPO) Expression in Platelets of Depressed Patients Decreases during Antidepressant Therapy

Sarubin, N. ; Baghai, T. ; Lima-Ojeda, J. ; Melchner, D. ; Hallof-Buestrich, H. ; Wolf, L. ; Hilbert, S. ; Milenkovic, V. ; Wetzel, C. ; Rupprecht, R. ; Nothdurfter, C.



Zusammenfassung

Introduction: A promising candidate in the field of pharmacological treatment options regarding major depressive disorder (MDD) is the mitochondrial translocator protein (18 kDa) (TSPO). TSPO is crucial for neurosteroid synthesis, which is in turn important for the regulation of emotions. It has already been shown that TSPO expression in platelets of depressed patients is reduced compared to ...

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