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Inactivation of the LKB1-AMPK signaling pathway does not contribute to salivary gland tumor development - a short report

Cidlinsky, Natascha ; Dogliotti, Giada ; Pukrop, Tobias ; Jung, Rudolf ; Weber, Florian ; Krahn, Michael P.



Abstract

Activation of AMPK by the tumor suppressor LKB1 represents an essential gatekeeping step for cells under energetic stress to prevent their growth and proliferation by inhibiting mTOR activation, until the energy supply normalizes. The LKB1/AMPK pathway is frequently downregulated in various types of cancer, thereby uncoupling tumor cell growth and proliferation from energy supply. As yet, little ...

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