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The PIN domain endonuclease Utp24 cleaves pre-ribosomal RNA at two coupled sites in yeast and humans

Wells, Graeme R. ; Weichmann, Franziska ; Colvin, David ; Sloan, Katherine E. ; Kudla, Grzegorz ; Tollervey, David ; Watkins, Nicholas J. ; Schneider, Claudia


During ribosomal RNA (rRNA) maturation, cleavages at defined sites separate the mature rRNAs from spacer regions, but the identities of several enzymes required for 18S rRNA release remain unknown. PilT N-terminus (PIN) domain proteins are frequently endonucleases and the PIN domain protein Utp24 is essential for early cleavages at three pre-rRNA sites in yeast (A0, A1 and A2) and humans (A0, 1 ...


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