; Schmidt, Ellen M.
; Johnson, Toby ; Thorleifsson, Gudmar ; Luan, Jian'an ; Donnelly, Louise A. ; Kanoni, Stavroula ; Petersen, Ann-Kristin ; Pihur, Vasyl ; Strawbridge, Rona J.
; Shungin, Dmitry ; Hughes, Maria F.
; Meirelles, Osorio ; Kaakinen, Marika ; Bouatia-Naji, Nabila ; Kristiansson, Kati ; Shah, Sonia
; Kleber, Marcus E. ; Guo, Xiuqing ; Lyytikäinen, Leo-Pekka ; Fava, Cristiano ; Eriksson, Niclas
; Nolte, Ilja M. ; Magnusson, Patrik K.
; Salfati, Elias L. ; Rallidis, Loukianos S. ; Theusch, Elizabeth ; Smith, Andrew J. P.
; Folkersen, Lasse
; Witkowska, Kate ; Pers, Tune H.
; Joehanes, Roby ; Kim, Stuart K. ; Lataniotis, Lazaros ; Jansen, Rick
; Johnson, Andrew D. ; Warren, Helen ; Kim, Young Jin ; Zhao, Wei
; Wu, Ying ; Tayo, Bamidele O. ; Bochud, Murielle ; Absher, Devin ; Adair, Linda S. ; Amin, Najaf
; Arking, Dan E. ; Axelsson, Tomas ; Baldassarre, Damiano
; Balkau, Beverley ; Bandinelli, Stefania ; Barnes, Michael R.
; Barroso, Inês
; Bevan, Stephen
; Bis, Joshua C. ; Bjornsdottir, Gyda ; Boehnke, Michael ; Boerwinkle, Eric ; Bonnycastle, Lori L. ; Boomsma, Dorret I. ; Bornstein, Stefan R. ; Brown, Morris J. ; Burnier, Michel ; Cabrera, Claudia P. ; Chambers, John C. ; Chang, I-Shou ; Cheng, Ching-Yu ; Chines, Peter S. ; Chung, Ren-Hua ; Collins, Francis S. ; Connell, John M. ; Döring, Angela ; Dallongeville, Jean ; Danesh, John ; de Faire, Ulf ; Delgado, Graciela ; Dominiczak, Anna F. ; Doney, Alex S. F.
; Drenos, Fotios ; Edkins, Sarah ; Eicher, John D. ; Elosua, Roberto ; Enroth, Stefan
; Erdmann, Jeanette
; Eriksson, Per
; Esko, Tonu ; Evangelou, Evangelos
; Evans, Alun ; Fall, Tove ; Farrall, Martin ; Felix, Janine F. ; Ferrières, Jean
; Ferrucci, Luigi ; Fornage, Myriam ; Forrester, Terrence ; Franceschini, Nora ; Franco, Oscar H. ; Franco-Cereceda, Anders ; Fraser, Ross M. ; Ganesh, Santhi K. ; Gao, He ; Gertow, Karl ; Gianfagna, Francesco
; Gigante, Bruna
; Giulianini, Franco ; Goel, Anuj ; Goodall, Alison H.
; Goodarzi, Mark O. ; Gorski, Mathias ; Gräßler, Jürgen ; Groves, Christopher J. ; Gudnason, Vilmundur ; Gyllensten, Ulf ; Hallmans, Göran ; Hartikainen, Anna-Liisa ; Hassinen, Maija ; Havulinna, Aki S. ; Hayward, Caroline ; Hercberg, Serge ; Herzig, Karl-Heinz ; Hicks, Andrew A.
; Hingorani, Aroon D. ; Hirschhorn, Joel N. ; Hofman, Albert ; Holmen, Jostein ; Holmen, Oddgeir Lingaas ; Hottenga, Jouke-Jan ; Howard, Phil ; Hsiung, Chao A. ; Hunt, Steven C. ; Ikram, M. Arfan ; Illig, Thomas ; Iribarren, Carlos ; Jensen, Richard A. ; Kähönen, Mika
; Kang, Hyun Min ; Kathiresan, Sekar ; Keating, Brendan J. ; Khaw, Kay-Tee ; Kim, Yun Kyoung ; Kim, Eric ; Kivimaki, Mika ; Klopp, Norman ; Kolovou, Genovefa ; Komulainen, Pirjo ; Kooner, Jaspal S. ; Kosova, Gulum ; Krauss, Ronald M. ; Kuh, Diana ; Kutalik, Zoltan ; Kuusisto, Johanna ; Kvaløy, Kirsti ; Lakka, Timo A. ; Lee, Nanette R. ; Lee, I-Te ; Lee, Wen-Jane ; Levy, Daniel ; Li, Xiaohui ; Liang, Kae-Woei ; Lin, Honghuang
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; Yang, Tsun-Po
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; Zhang, Weihua ; Zhao, Jing Hua
; Zhu, Xiaofeng ; Bovet, Pascal
; Cooper, Richard S. ; Mohlke, Karen L. ; Saleheen, Danish ; Lee, Jong-Young ; Elliott, Paul
; Gierman, Hinco J. ; Willer, Cristen J. ; Franke, Lude
; Hovingh, G. Kees ; Taylor, Kent D. ; Dedoussis, George ; Sever, Peter ; Wong, Andrew
; Lind, Lars ; Assimes, Themistocles L.
; Njølstad, Inger ; Schwarz, Peter E. H. ; Langenberg, Claudia
; Snieder, Harold ; Caulfield, Mark J.
; Melander, Olle ; Laakso, Markku ; Saltevo, Juha ; Rauramaa, Rainer ; Tuomilehto, Jaakko ; Ingelsson, Erik ; Lehtimäki, Terho ; Hveem, Kristian ; Palmas, Walter ; März, Winfried ; Kumari, Meena ; Salomaa, Veikko ; Chen, Yii-Der I. ; Rotter, Jerome I. ; Froguel, Philippe ; Jarvelin, Marjo-Riitta
; Lakatta, Edward G. ; Kuulasmaa, Kari
; Franks, Paul W.
; Hamsten, Anders ; Wichmann, H.-Erich ; Palmer, Colin N. A.
; Stefansson, Kari ; Ridker, Paul M. ; Loos, Ruth J. F.
; Chakravarti, Aravinda ; Deloukas, Panos
; Morris, Andrew P. ; Newton-Cheh, Christopher ; Munroe, Patricia B. | Dokumentenart: | Artikel | ||||
|---|---|---|---|---|---|
| Titel eines Journals oder einer Zeitschrift: | Nature Genetics | ||||
| Verlag: | Nature | ||||
| Ort der Veröffentlichung: | NEW YORK | ||||
| Band: | 48 | ||||
| Nummer des Zeitschriftenheftes oder des Kapitels: | 10 | ||||
| Seitenbereich: | S. 1171-1184 | ||||
| Datum: | 2016 | ||||
| Institutionen: | Medizin > Institut für Epidemiologie und Präventivmedizin | ||||
| Identifikationsnummer: |
| ||||
| Stichwörter / Keywords: | GENOME-WIDE ASSOCIATION; ARTERIAL-HYPERTENSION; COMMON VARIANTS; CELL-TYPES; LOCI; TRAITS; CHROMATIN; SUSCEPTIBILITY; METAANALYSIS; BIOLOGY; | ||||
| Dewey-Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin | ||||
| Status: | Veröffentlicht | ||||
| Begutachtet: | Ja, diese Version wurde begutachtet | ||||
| An der Universität Regensburg entstanden: | Ja | ||||
| Dokumenten-ID: | 42992 |
Zusammenfassung
To dissect the genetic architecture of blood pressure and assess effects on target organ damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 individuals of European ancestry, and genotypes from an additional 140,886 individuals were used for validation. We identified 66 blood pressure-associated loci, of which 17 were new; 15 harbored multiple distinct association ...

Zusammenfassung
To dissect the genetic architecture of blood pressure and assess effects on target organ damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 individuals of European ancestry, and genotypes from an additional 140,886 individuals were used for validation. We identified 66 blood pressure-associated loci, of which 17 were new; 15 harbored multiple distinct association signals. The 66 index SNPs were enriched for cis-regulatory elements, particularly in vascular endothelial cells, consistent with a primary role in blood pressure control through modulation of vascular tone across multiple tissues. The 66 index SNPs combined in a risk score showed comparable effects in 64,421 individuals of non-European descent. The 66-SNP blood pressure risk score was significantly associated with target organ damage in multiple tissues but with minor effects in the kidney. Our findings expand current knowledge of blood pressure-related pathways and highlight tissues beyond the classical renal system in blood pressure regulation.
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