Direkt zum Inhalt

Prantl, Lukas ; Gerken, Michael ; Zeman, Florian ; Leitzmann, Michael ; Koller, Michael ; Klinkhammer-Schalke, Monika ; Evert, Matthias ; Kuehlmann, Britta ; Biermann, Niklas

Incidence of Anaplastic Large Cell Lymphoma and Breast-Implant-Associated Lymphoma—An Analysis of a Certified Tumor Registry over 17 Years

Prantl, Lukas, Gerken, Michael, Zeman, Florian, Leitzmann, Michael, Koller, Michael, Klinkhammer-Schalke, Monika, Evert, Matthias, Kuehlmann, Britta und Biermann, Niklas (2020) Incidence of Anaplastic Large Cell Lymphoma and Breast-Implant-Associated Lymphoma—An Analysis of a Certified Tumor Registry over 17 Years. Journal of Clinical Medicine 9 (5), S. 1247.

Veröffentlichungsdatum dieses Volltextes: 13 Mai 2020 10:25
Artikel
DOI zum Zitieren dieses Dokuments: 10.5283/epub.43188


Zusammenfassung

Background: Breast-implant-associated anaplastic large cell lymphoma (BI-ALCL) and primary breast ALCL are rare extranodal manifestations of non-Hodgkin lymphoma. The rarity of both diseases, along with unreleased sales data on breast implants and constant updates of classification systems impede the calculation of an exact incidence. Methods: The database of the Tumor Center Regensburg in ...

Background: Breast-implant-associated anaplastic large cell lymphoma (BI-ALCL) and primary breast ALCL are rare extranodal manifestations of non-Hodgkin lymphoma. The rarity of both diseases, along with unreleased sales data on breast implants and constant updates of classification systems impede the calculation of an exact incidence. Methods: The database of the Tumor Center Regensburg in Bavaria was searched for patients with CD30-positive and ALK-negative anaplastic large cell lymphoma between 2002 and 2018. These lymphomas were identified by the ICD-O-3 morphology code "97023" and were cross-checked by searching the diagnosis by name the and ICD-10 code C84.7. Furthermore, we tried to calculate the incidence rates and corresponding 95% confidence intervals, standardized to 1,000,000 implant years of breast-implant-associated anaplastic large cell lymphoma and primary breast anaplastic large cell lymphoma. Results: Twelve ALK-negative and CD30-positive anaplastic large cell lymphomas were identified out of 170,405 malignancies. No case was found within the breast tissue and none of the patients had a previous history of breast implant placement. In five cases, lymph node involvement in close proximity to the breast was observed. Conclusion: We found a low incidence of anaplastic large cell lymphoma and no association to breast implants in these patients. A review of the current literature revealed inconsistent use of classification systems for anaplastic large cell lymphomas and potential overestimation of cases.



Beteiligte Einrichtungen


Details

DokumentenartArtikel
Titel eines Journals oder einer ZeitschriftJournal of Clinical Medicine
Verlag:MDPI
Ort der Veröffentlichung:BASEL
Band:9
Nummer des Zeitschriftenheftes oder des Kapitels:5
Seitenbereich:S. 1247
Datum25 April 2020
InstitutionenMedizin > Lehrstuhl für Pathologie
Medizin > Zentren des Universitätsklinikums Regensburg > Zentrum für Klinische Studien
Medizin > Zentren des Universitätsklinikums Regensburg > Tumorzentrum e.V.
Medizin > Institut für Epidemiologie und Präventivmedizin > Tumorzentrum e.V.

Medizin > Zentren des Universitätsklinikums Regensburg > Zentrum für Plastische-, Hand- und Wiederherstellungschirurgie
Medizin > Institut für Epidemiologie und Präventivmedizin
Identifikationsnummer
WertTyp
10.3390/jcm9051247DOI
Stichwörter / KeywordsWOMEN; RISK; EPIDEMIOLOGY; TRENDS; anaplastic large cell lymphoma; CD-30 positive; ALK-negative; breast implants; incidence
Dewey-Dezimal-Klassifikation600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin
StatusVeröffentlicht
BegutachtetJa, diese Version wurde begutachtet
An der Universität Regensburg entstandenJa
URN der UB Regensburgurn:nbn:de:bvb:355-epub-431882
Dokumenten-ID43188

Bibliographische Daten exportieren

Nur für Besitzer und Autoren: Kontrollseite des Eintrags

nach oben