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Prantl, Lukas ; Gerken, Michael ; Zeman, Florian ; Leitzmann, Michael ; Koller, Michael ; Klinkhammer-Schalke, Monika ; Evert, Matthias ; Kuehlmann, Britta ; Biermann, Niklas

Incidence of Anaplastic Large Cell Lymphoma and Breast-Implant-Associated Lymphoma—An Analysis of a Certified Tumor Registry over 17 Years

Prantl, Lukas, Gerken, Michael, Zeman, Florian, Leitzmann, Michael, Koller, Michael, Klinkhammer-Schalke, Monika, Evert, Matthias, Kuehlmann, Britta and Biermann, Niklas (2020) Incidence of Anaplastic Large Cell Lymphoma and Breast-Implant-Associated Lymphoma—An Analysis of a Certified Tumor Registry over 17 Years. Journal of Clinical Medicine 9 (5), p. 1247.

Date of publication of this fulltext: 13 May 2020 10:25
Article
DOI to cite this document: 10.5283/epub.43188


Abstract

Background: Breast-implant-associated anaplastic large cell lymphoma (BI-ALCL) and primary breast ALCL are rare extranodal manifestations of non-Hodgkin lymphoma. The rarity of both diseases, along with unreleased sales data on breast implants and constant updates of classification systems impede the calculation of an exact incidence. Methods: The database of the Tumor Center Regensburg in ...

Background: Breast-implant-associated anaplastic large cell lymphoma (BI-ALCL) and primary breast ALCL are rare extranodal manifestations of non-Hodgkin lymphoma. The rarity of both diseases, along with unreleased sales data on breast implants and constant updates of classification systems impede the calculation of an exact incidence. Methods: The database of the Tumor Center Regensburg in Bavaria was searched for patients with CD30-positive and ALK-negative anaplastic large cell lymphoma between 2002 and 2018. These lymphomas were identified by the ICD-O-3 morphology code "97023" and were cross-checked by searching the diagnosis by name the and ICD-10 code C84.7. Furthermore, we tried to calculate the incidence rates and corresponding 95% confidence intervals, standardized to 1,000,000 implant years of breast-implant-associated anaplastic large cell lymphoma and primary breast anaplastic large cell lymphoma. Results: Twelve ALK-negative and CD30-positive anaplastic large cell lymphomas were identified out of 170,405 malignancies. No case was found within the breast tissue and none of the patients had a previous history of breast implant placement. In five cases, lymph node involvement in close proximity to the breast was observed. Conclusion: We found a low incidence of anaplastic large cell lymphoma and no association to breast implants in these patients. A review of the current literature revealed inconsistent use of classification systems for anaplastic large cell lymphomas and potential overestimation of cases.



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Details

Item typeArticle
Journal or Publication TitleJournal of Clinical Medicine
Publisher:MDPI
Place of Publication:BASEL
Volume:9
Number of Issue or Book Chapter:5
Page Range:p. 1247
Date25 April 2020
InstitutionsMedicine > Lehrstuhl für Pathologie
Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Klinische Studien
Medicine > Zentren des Universitätsklinikums Regensburg > Tumorzentrum e.V.
Medicine > Institut für Epidemiologie und Präventivmedizin > Tumorzentrum e.V.

Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Plastische-, Hand- und Wiederherstellungschirurgie
Medicine > Institut für Epidemiologie und Präventivmedizin
Identification Number
ValueType
10.3390/jcm9051247DOI
KeywordsWOMEN; RISK; EPIDEMIOLOGY; TRENDS; anaplastic large cell lymphoma; CD-30 positive; ALK-negative; breast implants; incidence
Dewey Decimal Classification600 Technology > 610 Medical sciences Medicine
StatusPublished
RefereedYes, this version has been refereed
Created at the University of RegensburgYes
URN of the UB Regensburgurn:nbn:de:bvb:355-epub-431882
Item ID43188

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