Incidence of Anaplastic Large Cell Lymphoma and Breast-Implant-Associated Lymphoma—An Analysis of a Certified Tumor Registry over 17 Years

Prantl, Lukas ; Gerken, Michael ; Zeman, Florian ; Leitzmann, Michael ; Koller, Michael ; Klinkhammer-Schalke, Monika ; Evert, Matthias ; Kuehlmann, Britta ; Biermann, Niklas

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Date of publication of this fulltext: 13 May 2020 10:25

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Details

Item type:	Article
Journal or Publication Title:	Journal of Clinical Medicine
Publisher:	MDPI
Volume:	9
Number of Issue or Book Chapter:	5
Page Range:	p. 1247
Date:	25 April 2020
Institutions:	Medicine > Lehrstuhl für Chirurgie
Projects:	Open Access Publizieren (DFG)
Identification Number:	Value Type 10.3390/jcm9051247 DOI
Keywords:	anaplastic large cell lymphoma; CD-30 positive; ALK-negative; breast implants; incidence
Dewey Decimal Classification:	600 Technology > 610 Medical sciences Medicine
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Yes
Item ID:	43188

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Abstract

Background: Breast-implant-associated anaplastic large cell lymphoma (BI-ALCL) and primary breast ALCL are rare extranodal manifestations of non-Hodgkin lymphoma. The rarity of both diseases, along with unreleased sales data on breast implants and constant updates of classification systems impede the calculation of an exact incidence. Methods: The database of the Tumor Center Regensburg in ...

Abstract

Background: Breast-implant-associated anaplastic large cell lymphoma (BI-ALCL) and primary breast ALCL are rare extranodal manifestations of non-Hodgkin lymphoma. The rarity of both diseases, along with unreleased sales data on breast implants and constant updates of classification systems impede the calculation of an exact incidence. Methods: The database of the Tumor Center Regensburg in Bavaria was searched for patients with CD30-positive and ALK-negative anaplastic large cell lymphoma between 2002 and 2018. These lymphomas were identified by the ICD-O-3 morphology code “97023” and were cross-checked by searching the diagnosis by name the and ICD-10 code C84.7. Furthermore, we tried to calculate the incidence rates and corresponding 95% confidence intervals, standardized to 1,000,000 implant years of breast-implant-associated anaplastic large cell lymphoma and primary breast anaplastic large cell lymphoma. Results: Twelve ALK-negative and CD30-positive anaplastic large cell lymphomas were identified out of 170,405 malignancies. No case was found within the breast tissue and none of the patients had a previous history of breast implant placement. In five cases, lymph node involvement in close proximity to the breast was observed. Conclusion: We found a low incidence of anaplastic large cell lymphoma and no association to breast implants in these patients. A review of the current literature revealed inconsistent use of classification systems for anaplastic large cell lymphomas and potential overestimation of cases.

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