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Brain Exposure to Piperacillin in Acute Hemorrhagic Stroke Patients Assessed by Cerebral Microdialysis and Population Pharmacokinetics

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Ullah, Sami ; Beer, Ronny ; Fuhr, Uwe ; Taubert, Max ; Zeitlinger, Markus ; Kratzer, Alexander ; Dorn, Christoph ; Arshad, Usman ; Kofler, Mario ; Helbok, Raimund
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 18 Jun 2020 07:53


Background The broad antibacterial spectrum of piperacillin/tazobactam makes the combination suitable for the treatment of nosocomial bacterial central nervous system (CNS) infections. As limited data are available regarding piperacillin CNS exposure in patients without or with low-grade inflammation, a clinical study was conducted (1) to quantify CNS exposure of piperacillin by cerebral ...


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