Go to content
UR Home

Linkage between catalytic mechanism and conformational dynamics in (βα)₈-barrel enzymes at the example of Imidazole Glycerol Phosphate Synthase

URN to cite this document:
DOI to cite this document:
Hupfeld, Enrico
Date of publication of this fulltext: 30 Jun 2021 06:10

Abstract (English)

Imidazole glycerol phosphate synthase (ImGPS) is a bienzyme complex from histidine biosynthesis, which consists of the cyclase subunit HisF and the glutaminase subunit HisH. In HisH, glutamine is hydrolysed to glutamate and ammonia, which is channelled through an intramolecular tunnel to the HisF active site, where it reacts with N’-[(5’-phosphoribulosyl)-formimino]-5-aminoimidazole-4-carboxamide ...


Translation of the abstract (German)

Die Imidazolglycerinphosphatsynthase (ImGPS) ist ein Bienzymkomplex aus der Histidinbiosynthese, welcher aus der Cyclaseuntereinheit HisF und der Glutaminaseuntereinheit HisH besteht. In HisH wird Glutamin zu Glutamat und Ammoniak hydrolysiert, der dann durch einen intramolekularen Kanal zum aktiven Zentrum von HisF gelangt und dort mit ...


Owner only: item control page
  1. Homepage UR

University Library

Publication Server


Publishing: oa@ur.de
0941 943 -4239 or -69394

Dissertations: dissertationen@ur.de
0941 943 -3904

Research data: datahub@ur.de
0941 943 -5707

Contact persons