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Design, Synthesis and Characterization of Molecular Tools for the Histamine H3 and H4 Receptors – In Particular Radio- and Fluorescent Ligands

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Bartole, Edith
Date of publication of this fulltext: 18 Oct 2021 06:31

Abstract (English)

Over the years, the histamine H3 and H4 receptors have emerged as promising therapeutic targets. By contrast to the H3R, the number of drug candidates for the H4R is very limited. Possible reasons are the not fully elucidated expression pattern of the H4R and the marked species [human (h), mouse (m), rat (r)]-dependent differences, regarding affinities, potencies and/or the quality of action of ...


Translation of the abstract (German)

Radio- und Fluoreszenzliganden mit einem speziesübergreifend ausgewogenen Affinitäts-/ Funktionalitätsprofil an den Histamin H4 Rezeptor (H4R) Orthologen [Mensch (h), Maus (m), Ratte (r)] stellen wertvolle molekulare Werkzeuge dar, um mit Hilfe von Nagermodellen ein tieferes Verständnis für den H4R zu erhalten. Allerdings ist bisher kein Radioligand beschrieben, der sich für robuste ...


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