Robust Metabolite Quantification from J-Compensated 2D 1H-13C-HSQC Experiments

URN to cite this document:: urn:nbn:de:bvb:355-epub-441645
DOI to cite this document:: 10.5283/epub.44164

Weitzel, Alexander ; Samol, Claudia ; Oefner, Peter J. ; Gronwald, Wolfram

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Date of publication of this fulltext: 13 Nov 2020 05:50

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Abstract

The spectral resolution of 2D H-1-C-13 heteronuclear single quantum coherence (H-1-C-13-HSQC) nuclear magnetic resonance (NMR) spectra facilitates both metabolite identification and quantification in nuclear magnetic resonance-based metabolomics. However, quantification is complicated by variations in magnetization transfer, which among others originate mainly from scalar coupling differences. ...