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Hexamerization and thermostability emerged very early during geranylgeranylglyceryl phosphate synthase evolution

URN to cite this document:
urn:nbn:de:bvb:355-epub-446005
DOI to cite this document:
10.5283/epub.44600
Kropp, Cosimo ; Straub, Kristina ; Linde, Mona ; Babinger, Patrick
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License: Creative Commons Attribution Non-commercial 4.0
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Date of publication of this fulltext: 27 Jan 2021 06:01


Abstract

A large number of archaea live in hyperthermophilic environments. In consequence, their proteins need to adopt to these harsh conditions, including the enzymes that catalyze the synthesis of their membrane ether lipids. The enzyme that catalyzes the formation of the first ether bond in these lipids, geranylgeranylglyceryl phosphate synthase (GGGPS), exists as a hexamer in many hyperthermophilic ...

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