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Modeling and Bioinformatics Identify Responders to G-CSF in Patients With Amyotrophic Lateral Sclerosis

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Johannesen, Siw Wollebæk ; Huie, J. Russell ; Budeus, Bettina ; Peters, Sebastian ; Wirth, Anna M. ; Iberl, Sabine ; Kammermaier, Tina ; Kobor, Ines ; Wirkert, Eva ; Küspert, Sabrina ; Tahedl, Marlene ; Grassinger, Jochen ; Pukrop, Tobias ; Schneider, Armin ; Aigner, Ludwig ; Schulte-Mattler, Wilhelm ; Schuierer, Gerhard ; Koch, Winfried ; Bruun, Tim-Henrik ; Ferguson, Adam R. ; Bogdahn, Ulrich
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 18 Mar 2021 17:22


Objective: Developing an integrative approach to early treatment response classification using survival modeling and bioinformatics with various biomarkers for early assessment of filgrastim (granulocyte colony stimulating factor) treatment effects in amyotrophic lateral sclerosis (ALS) patients. Filgrastim, a hematopoietic growth factor with excellent safety, routinely applied in oncology and ...


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